HDinHD (Huntington’s Disease in High Definition; HDinHD.org) is an open online portal for the HD research community that presents a synthesized view of HD-related, largely pre-clinical, scientific data.
The goal of HDinHD is to foster and support a collaborative community united in its drive to accelerate the development of therapeutics that will delay the onset and/or ameliorate the effects of Huntington’s disease. HDinHD seeks to achieve this through:
We highlight several components from HDinHD’s Downloads and Tools sections below.
An overview of HDinHD componentry, featuring a demonstration of the HD Explorer.
This video was originally presented at the annual CHDI HD Therapeutics Conference, April 27-29 2021.
The following tools were developed by the Genetic Modifiers of Huntington’s Disease (GeM-HD) Consortium in order to provide access to genome-wide findings from Huntington’s disease genetic modifiers analyses.
GeM MOA SNP Viewer
GeM Euro 9K
HD Explorer presents an integrated network of HD experimental data curated and analyzed from the literature, community ‘omics repositories and newly-released internal CHDI reports. HD Explorer includes the following components:
Current as of Jan1, 2023
Current as of Jan 1, 2023
Molecular signatures in mouse striatum
Our partners at Rancho BioSciences performed a comprehensive analysis of gene and protein data generated from an allelic series of knock-in (KI) mice containing an increasing number of CAG repeats. A 266 striatal gene disease signature and a 115 striatal protein disease signature were developed and validated in external datasets. These signatures represent molecular readouts of disease progression in models of HD mice, further characterize their HD-related phenotype and can be useful in the preclinical evaluation of candidate therapeutic interventions.
The Downloads section of HDinHD includes a Striatum Disease signature section, containing the following:
The manuscript can also be downloaded from the bioRxiv.