Joining the Starting Lineup: MutLβ’s Role in DNA Repeat Expansions
⏱️8 min read | Scientists have known that MutLβ is linked to repeat expansion but not exactly how. A study reveals that the MutLβ protein complex is a main player supporting and interacting with key DNA repair proteins to drive DNA repeat expansions. Read more
Catching a Giant Protein: Five New Ways to Grab Huntingtin
⏱️8 min read | Scientists screened over a trillion tiny ring-shaped protein fragments to find ones that can grab onto the huntingtin. They captured huntingtin straight out of cells and discovered it’s almost always paired with a partner called HAP40. Read more
Mirror, Mirror on the Wall: When Self-Awareness Shifts in Huntington’s Disease
⏱️6 min read | A new study suggests that reduced awareness of symptoms, known as anosognosia, may appear even in the earliest stages of HD. The findings highlight that understanding symptom progression requires more than one perspective. Read more
More Than Just Food: The Hidden Challenges of Eating with Huntington’s Disease
⏱️8 min read | People with Huntington’s disease commonly experience unintended weight loss. A recent article identified the challenges around HD’s impact on eating and weight maintenance, and explored how families and professionals navigate them. Read more
Roche ends two Huntington’s disease drug programmes after disappointing results
⏱️ 10 min read | Roche announced it is stopping development of two of its huntingtin-lowering ASO drugs, tominersen and RG6496. This marks a disappointing end to an important chapter in HD clinical research. Read more
Are we finally getting that PET we’ve always wanted?
⏱️8 min read | For the past 20 years, PET tracers have been a game-changer for Alzheimer’s disease, making it possible to see amyloid plaques in the brain without invasive procedures. So what about Huntington’s? Read more
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