Excitement and Anticipation as PTC’s Huntington’s Disease Drug Clears a Major Hurdle to Sprint Home
On May 5th, PTC Therapeutics released results from their ongoing Phase 2 PIVOT-HD clinical trial for PTC-518, now called votoplam. Excitingly, they announced that this trial met its primary endpoint – votoplam was shown to lower huntingtin protein levels. We also learned more about the safety of this drug and some insights into how it […]
What’s Good for Your Heart is Good for Your Brain: New Study Links Cardiovascular Health to Brain Aging
We all know heart health matters – but what if the same habits that keep your heart strong could also protect your brain? A new study reveals a link between cardiovascular health and lower levels of neurofilament light (NfL), a key biomarker of brain cell damage for Huntington’s disease (HD) research. So what does this […]
Assembly Line Breakdown: Protein Production Problems in Huntington’s Disease
Imagine a vast and intricate factory, humming with activity. This factory isn’t manufacturing cars or electronics but rather the essential components that keep our bodies running. Inside each cell, thousands of tiny workers, known as proteins, perform highly specialized tasks. These proteins are responsible for everything from building cellular structures to sending messages and cleaning […]
April 2025: This Month in Huntington’s Disease Research
April was blooming with fresh updates from the world of Huntington’s disease (HD) research, and we’ve got your highlights right here! At HDBuzz, we’re always on the lookout for promising science, innovative ideas, and stories that bring hope. This month, we covered exciting breakthroughs in basic research, important clinical trial updates, and fresh perspectives on […]
Stopping C-A-G Repeat Expansion In Its Tracks
A new study led by researchers at University College London explored a promising new way to potentially slow down Huntington disease (HD) by reducing the levels of a key DNA repair protein, called MSH3. Using antisense oligonucleotides (ASOs)—a type of genetic therapy that targets RNA—the researchers successfully stopped C-A-G repeat expansions in lab-grown brain cells […]
Do Antidepressants Affect Cognitive Decline? There’s More To The Story For Huntington’s Disease
Two recent studies offer fresh insights into how antidepressants, often prescribed to help manage mood and anxiety, are prescribed in Huntington’s disease (HD) and might also influence cognitive decline. One study zooms in on medication use in HD, while the other takes a broader look at dementia and antidepressants. Together, they reveal a complex and […]
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