Emozione e attesa per il farmaco di PTC contro la malattia di Huntington che supera un ostacolo importante per tornare a casa
On May 5th, PTC Therapeutics released results from their ongoing Phase 2 PIVOT-HD clinical trial for PTC-518, now called votoplam. Excitingly, they announced that this trial met its primary endpoint – votoplam was shown to lower huntingtin protein levels. We also learned more about the safety of this drug and some insights into how it […]
Ciò che fa bene al cuore fa bene anche al cervello: un nuovo studio collega la salute cardiovascolare all'invecchiamento cerebrale
We all know heart health matters – but what if the same habits that keep your heart strong could also protect your brain? A new study reveals a link between cardiovascular health and lower levels of neurofilament light (NfL), a key biomarker of brain cell damage for Huntington’s disease (HD) research. So what does this […]
Guasto alla catena di montaggio: problemi di produzione proteica nella malattia di Huntington
Imagine a vast and intricate factory, humming with activity. This factory isn’t manufacturing cars or electronics but rather the essential components that keep our bodies running. Inside each cell, thousands of tiny workers, known as proteins, perform highly specialized tasks. These proteins are responsible for everything from building cellular structures to sending messages and cleaning […]
Aprile 2025: questo mese nella ricerca sulla malattia di Huntington
April was blooming with fresh updates from the world of Huntington’s disease (HD) research, and we’ve got your highlights right here! At HDBuzz, we’re always on the lookout for promising science, innovative ideas, and stories that bring hope. This month, we covered exciting breakthroughs in basic research, important clinical trial updates, and fresh perspectives on […]
Arrestare sul nascere l'espansione della ripetizione CAG
A new study led by researchers at University College London explored a promising new way to potentially slow down Huntington disease (HD) by reducing the levels of a key DNA repair protein, called MSH3. Using antisense oligonucleotides (ASOs)—a type of genetic therapy that targets RNA—the researchers successfully stopped C-A-G repeat expansions in lab-grown brain cells […]
Gli antidepressivi influenzano il declino cognitivo? C'è molto di più da dire sulla malattia di Huntington
Due studi recenti offrono nuove prospettive su come gli antidepressivi, spesso prescritti per aiutare a gestire l'umore e l'ansia, vengano prescritti nella malattia di Huntington (MH) e potrebbero anche influenzare il declino cognitivo. Uno studio si concentra sull'uso dei farmaci nella MH, mentre l'altro esamina più ampi aspetti della demenza e degli antidepressivi. Insieme, rivelano un quadro complesso e […]
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